ACADEMIC PUBLICATIONS
- Three states of stromal cells–solid, liquid, and aerosol–and innovative delivery methods not previously reported
- Diet (Fat-free) Fat Grafting: The Truth behind the Mechanical Stromal Cell Transfers
- Indication-based protocols with different solutions for mechanical stromal-cell transfer
- New Mechanical Fat Separation Technique: Adjustable Regenerative Adipose-tissue Transfer (ARAT) and Mechanical Stromal Cell Transfer (MEST)
- Supercharged Mechanical Stromal-cell Transfer (MEST)
ADINIZER
FFDA, CE, KFDA, TGA Approved
Ultra-sharp Blade System
FFDA, CE, KFDA, TGA Approved
The first and only patented
Adipose tissue /stromal cell separation kit in the world
APPLICATIONS
MEST
(Mechanic Stromal-Cell Transfer)
Obtaining stromal (regenerative cells) from adipose tissue using ultra-precise blades.
ARAT
(Adjustable Regenerative Adipose-tissue Transfer)
Giving fat tissue the desired size and putting stromal cells into regenerative mode using ultra-sharp blades.
SUPERCHARGED
Ensuring maximum regeneration by using both fat-derived (with Adiner) and blood-derived (with PvRP) regenerative cells in combination. MEST + PvRP
DETAILSPrinciples
ADINIZER is a "revolutionary" kit allowing mechanically obtaining stromal cells from adipose tissue and at the same time bringing the fat tissue to the desired size without disturbing its vitality. By using ultra-sharp blades, strong bonds and bridges between parenchymal (adipocytes) and stromal (regenerative) cells in the adipose tissue are cut, thus obtaining the desired size of adipose tissue and collecting all stromal cells with the highest vitality and rate.
There are two different types of cells in all tissues and organs in our body. These are the "parenchymal cells" responsible for the organ's function and the "stromal" cells that support them. Parenchymal cells deteriorate, wear out or die due to old age, accidents, diseases and many internal and external reasons. In this case, stromal cells support, repair and "regenerate" with a more accurate definition, ensuring the continuation of life. Fat tissue is the most important and biggest regenerative cell source of the body.
How to obtain the most effective stromal-cell from adipose tissue?
Regenerative cells can be obtained from adipose tissue by 3 different methods. These are: Enzymatic, automatic machines and mechanical methods. In enzymatic methods, a foreign chemical substance is put into the biological tissue and a laboratory with cGMP and cGLP standards is required for this process. Enzymes are also used in automatic machines, and this is quite costly. Mechanical methods are the simplest, cheapest, and easiest methods. In Sesé’s study in 2021, DNA analysis proved that 10 times more cells than the enzyme can be obtained by mechanical method.
Adinizer is a "revolutionary" kit that changes paradigms. Because:
- It provides more successful stromal cell extraction from crushing by using ultra-sharp blades instead of enzyme,
- It allows stromal cells in sleep mode to switch to regenerative mode.
- It allows the fat tissues to reach the desired dimensions without disturbing their vitality. This allows different sizes of fat grafts to be applied to different areas and depths, just like in hyaluronic acid applications.
- It is the first and only patented ultra-sharp blade system in the world.
Obtaining stroma-cells from adipose tissue by the mechanical pathway both ensures maximum cell number and diversity, and, unlike the enzyme, ensures the presence of the environment (niche), which is absolutely necessary for the desired regenerative effect by protecting the ECM (extra-cellular matrix). Mechanical methods are therefore the most advantageous methods.
Fat tissue is the most ideal filling material in our body. It has been used for centuries not only in the face area but also in many areas of the body. There are 2 main problems in fat graft applications. These are: 1. Persistence/adhesion ratio 2. Larger than necessary, being noticed or palpated in buds.
How can the problems in fat graft applications be solved?
Maximum stromal cell support is needed in order for the adipose tissue to adhere to the area where it is placed and to remain for a long time. This happens either by adding extra stromal cells/SVF or activating stromal cells. You can only achieve this with the ultra-sharp blade system, ADINIZER. The biggest problem of the fat graft, especially in applications around the eyes or genital area where the skin is thin, is that it is in a visible format. You can only solve this by reducing the fat cells to the desired diameter, and there is only one kit in the world that provides this: ADINIZER
Effects of ADINIZER in Fat Application:
- It allows the fat tissue to be reduced to the desired diameter without disturbing its vitality.
- It releases stromal cells in adipose tissue and converts them from dormant mood to regenerative mode.
- It simultaneously provides rich fat graft from stromal cells.
- It prevents complications in fat graft applications, increases the chance of success.
ARAT is the most effective approach that changes the paradigm in fat grafting applications and also increases success.
VMost stromal (regenerative) cells in our body are found in two sources. These are adipose tissue and blood tissue. Combining the cells taken from the fat tissue by ADINIZER with the mechanical method, and from the blood by the system called COGS and the Platelet very Reach Plasma technique called PvRP provides maximum regeneration.
When is SUPERCHARGED approach needed?
In some special cases, it is necessary to combine all the regenerative resources of the body and create the maximum effect. Supercharged approach is preferred for both fast and effective results in ovarian insufficiency (MUSCAT procedure), hair restoration (STUNT-Procedure), Erectile dysfunction or orthopedic applications (OA, aseptic necrosis).
Advantages of the supercharged technique:
- Maximum broad spectrum with the combined application of both fat and blood-derived cells
- Potentialization of the effect
- Giving the maximum number and variety of cells to a small volume area
- Ensuring successful regeneration of difficult-to-treat situations
The supercharged technique is the most effective regenerative approach.
Applying the Adinizing with an ultra-sharp blade of only 400 microns allows the regenerative cells in the adipose tissue to switch from the dormant mode to the regenerative mode; at the same time a thinned oil/stromal-cell solution is obtained.
For whom is S-400 Superfat application useful?
This approach is preferred to increase the quality of the skin, to improve its thickness and structure, and especially if the regenerative (revitalization) process is at the forefront rather than the filling process.
Advantages of S-400 Superfat treatment
- In this approach, the main goal is to revitalize the quality of the adipose tissue rather than filling an area.
- It provides excellent results especially in décolleté, back of the hand, around the eyes and genital aesthetic applications.
- With a very simple application, it corrects the fine lines on the upper lip, which is called as smoker line.
- With only one blade and one cannula, it increases the quality of the skin, and provides a fresher appearance, in a very short time, like a youth vaccine.
S-400, Superfat application is a new perspective. As a 400-micron blade is used directly in this process, some of the adipocytes will be destroyed, but regeneration will be limited but effective as the stromal cells will enter the active phase.
PARTNERS
G-CAT ACADEMY
Gene, Cell and Tissue Academy. Gene, Cell and Tissue Academy. G-Cat Academy is an international academy of distinguished scientists and doctors from all over the world dealing with stem cell...
BSL-REST
BSL rest is a subsidiary organization of BSL Biosolution company from South Korea. The CEO and largest shareholder of the company is Junseok Lee, who also holds the most scientific patents in South...
